Endocrine Abstracts

The importance of endogenous hormones in the aetiology of breast cancer has long been evident from the strong relationships between breast cancer risk and certain aspects of a woman’s reproductive history1. More recently, the risk of developing breast cancer among postmenopausal women has also been shown to increase substantially with increasing levels of circulating oestradiol2, thus providing more direct evidence for the role of hormones in the development of the disea...

Objective: We aim to examine the effects of continuous glucose monitoring (CGM) within our local population by means of pre- and post-CGM introduction A1C, time spent in hypoglycaemia and time spent within personalised target.Methods: Retrospective study of the County Durham and Darlington Foundation Trust (CDDFT) patient group who use CGM was undertaken via the platform ‘twinkle’ and ‘diasend’. Results were graphed prior to statistic...

Background: Falls are a significant health problem and major burden on healthcare services. Falls are typically associated with ageing-related frailty, but diabetic peripheral neuropathy, postural hypotension and hyponatraemia are recognised risk factors for falling that might be independent of ageing-related factors. We undertook a study to assess the prevalence of these independent risk factors in patients admitted to hospital following a fall.Methods:...

PCOS is a reproductive endocrine disorder that affects up to 10% of women of a reproductive age, with 70-80% of patients defined as infertile. There are many different symptoms that could impact fertility in women with PCOS such as anovulation, hyperandrogenism and insulin resistance. A trophoblast (BeWo cell) spheroid attachment assay was used as an in vitro model of embryo implantation to examine the effect of testosterone on the receptivity of endometrial (Ishikawa...

Introduction: Type 1 Diabetes Mellitus (T1DM) causes autoimmune destruction of insulin producing b-cells, affecting approximately 8.4 million individuals worldwide. Autologous stem cell derived b cell (sc-b cell) transplantation is a promising treatment, however receipient immunological responses remain a challenge. This pilot study utilised mass cytometry (CyTOF) to assess immune responses in co-cultures of peripheral blood mononuclear cells (PBMC) with autol...

Hypophosphatasia (HPP), a heritable metabolic bone disease, results from low alkaline phosphatase (TNSALP) activity. Inorganic pyrophosphate (PPi), an inhibitor of mineralization, and pyridoxal 5′-phosphate (PLP), are substrates that accumulate in HPP. There is no approved therapy. ENB-0040, a bone-targeted, recombinant, human TNSALP improves skeletal mineralization in affected infants and children with HPP.Objective: Evaluate substrate levels and ...